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The effect of anabolic steroid administration on bupivacaine-induced regeneration of the mouse TA muscle from castrated mice has not been investigated. The purpose of this study was to determine whether mouse TA muscle regeneration from bupivacaine-induced injury was responsive to anabolic steroid administration. We hypothesized that ND administration would increase muscle mass accretion by stimulating IGF-I signaling and small myofiber formation during the first 2 wk of the regenerative process, which will support enhanced muscle growth at 42 days after injury, m1 alpha prohormone review.
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